Identification of N-acetyldopamine dimers from the dung beetle Catharsius molossus and their COX-1 and COX-2 inhibitory activities

DOI
10.3390/molecules200915589
Publication Year
2015
Publication Site
Molecules
Journal Volume
20
Page Numbers
15589–15596
Family
Scarabaeidae
Species 1 Binomial
General topic
Physiology
Specific topic
bioactive compounds
Author

Lu, J; Sun, Q; Tu, Z C; Lv, Q; Shui, P X; Cheng, Y X

Abstract Note

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A-C (1?3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2. © 2015 by the authors; licensee MDPI, Basel, Switzerland.